A 10-year old boy complains of pain and swelling around his right knee for a 3-week duration that has not improved with rest. His mother denies a history of trauma to the knee. A radiograph shows a destructive mixed lytic and blastic mass arising from metaphysis of the distal tumor. What is the most likely diagnosis?
Most likely diagnosis: osteosarcoma
Risk factors for developing this disease: prior irradiation, genetic predisposition ( parents with retinoblastoma), Paget’s disease of the bone and bone infarcts
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